I-Berberine: Ukusetyenziswa, iiNzuzo, izongezo kunye neziphumo ezisecaleni

I-Berberine inembali ende yokusetyenziswa kwiinkqubo zamayeza esintu, njengeAyurvedakunye namayeza aseMpuma Asia. Yikhemikhali enencasa ekrakra evela kwiintlobo ngeentlobo zezityalo, ezifana nehydrastis canadensis (goldenseal), icoptis chinensis (icoptis okanye i-goldenthread) kunye neberberis vulgaris (barberry). Uphando lubonisa ukuba i-berberine inokuba neempawu ze-antimicrobial kunye ne-antibiotic, kunye nefuthe elihle kwi-metabolism, kodwa ezinye iimvavanyo zeklinikhi ziyafuneka ukuze kuqinisekiswe ezi zibonelelo.

I-Berberine inokuba nezibonelelo ezininzi ze-physiological kunye nemisebenzi ye-pharmacological esibindini, kwizintso, entliziyweni nasengqondweni, enokuthi ibonelele ngenkxaso ye-metabolic. Ngokomzekelo, i-berberine ivuselela i-enzyme ye-AMP-activated protein kinase, apho uphando lubonisa ukuba lunceda ukulawula imetabolism, ukusebenza kweeseli kunye namanqanaba amandla.

IBerberine isetyenziselwa ikakhulu ukuba luncedoiswekile yegazi ephantsi, ukuphucula impilo ye-cardiovascular, ukunciphisa uxinzelelo lwe-oxidative kunyecholesterol ephantsi, kunye ne-anti-diarrheal, i-anti-inflammatory and anti-cancer effects, uthi uHeather Zwickey, Ph.D, uprofesa we-immunology kwi-National University of Natural Medicine ePortland, e-Oregon.

I-Berberine idla ngokufumaneka kwifom ye-capsule, kodwa yenziwe njengamathontsi esweni kunye neegels kwiimeko ezahlukeneyo zokuvuvukala kwesikhumba, amehlo okanye amalungu.

Izityalo ezininzi kunye nemifuno equkethe i-berberine isetyenziswe ngamayeza kangangamawaka eminyaka, kodwa uphando olungakumbi luyafuneka ukuqonda iindlela zokusebenza zekhompawundi kunye neziphumo zexesha elide. Oko kuthethiweyo, uphando lucebisa ukuba kunokunceda impilo yomntu ngeendlela ezininzi.

Ngamana Ukunceda ukwehlisa iSwekile yeGazi kunye nokuthintela ukuchasana ne-insulin

Uphononongo luka-2022 ngaphakathiIimolekyuliibonisa iberberine inokuncedaamanqanaba eglucose asezantsikuba yandisa imveliso ye-insulin kwaye iphucula uvakalelo lwe-insulin, nangona uphando olongezelelweyo lufunekayo ukuqonda ngokupheleleyo le miphumo[1].

Ngamana Ukunceda ukwehlisa iCholesterol

Uphando lubonisa ukuba i-berberine inokuba nefuthe elihle kwiI-cholesterol ye-LDLkunye necholesterol epheleleyo, nangona iimvavanyo ezongezelelweyo zeklinikhi ziyafuneka ukuqonda eli bango lezempilo ngokupheleleyo.

Ngamana ingaPhucula iMpilo ye-Cardiovascular

I-Berberine inokuba nefuthe elihle kwizicubu zentliziyo, ngakumbi kwiimeko ze-ischemia (ukungonelanga kwegazi), ngokuphucula amandla omzimba we-cardiac, ukunciphisa ukuvuvukala, ukunciphisa uxinzelelo lwe-oxidative, ukunciphisa uxinzelelo lwegazi kunye nokwandisa ukuphuma kwentliziyo.

Isenokuba neziphumo ezichasene nokudumba

I-Berberine yi-alkaloid ekrakra enika i-systemic anti-inflammatory effects, uthi u-Alicia McCubbins, ugqirha we-naturopathic osekelwe eVancouver, eWashington. Ezi zakhiwo zinokuthi zizuze iinkqubo ze-metabolic jikelele, ezifana nokuba negalelo ekukhuselweni kwe-atherosclerosis, uhlobo lwe-2 yeswekile, ukukhuluphala kunye neengxaki ze-cardiovascular. Iimpawu ezichasayo zeBerberine ziye zafundwa ixesha elide, kodwa indlela yokusebenza kwayo ayikaqondwa, igxininisa imfuno yophando olongezelelweyo.

Isenokuba neePropati zeAntioxidant

Uphononongo lwe-2018 kwiImida kwi-Pharmacologyugqiba kwelokuba iziphumo ze-berberine ze-antioxidant zithelekiswa ne-vitamin C, i-antioxidant enamandla kakhulu[2]. Izinto ezifana nevithamin C kunye neberberine zisebenza njenge-antioxidants ukunceda ukuthintela umonakalo onokuthi ubangele iiseli.

Isenokuba neePropati ze-Antibacterial kunye ne-Antimicrobial

"I-Berberine ineempawu ze-astringent kwaye ithathwa njenge-antimicrobial yendalo ekwazi ukukhupha ibhaktheriya, ii-parasites kunye ne-fungi / candida," wabelana noDkt McCubbins. Ezi zixhobo ze-antimicrobial zinokunceda ukuphucula iimeko ezithile, ezifana ne-acuteurhudo, isifo segazi, i-jaundice kunye nosulelo lobufazi, nangona uphando olungakumbi luyafuneka ukuxhasa la mabango. Ukuba umntu ukholelwa ukuba unosulelo lwebhaktheriya naluphi na uhlobo, kufuneka adibane nomboneleli wabo wezempilo ukuze axilongwe ngokufanelekileyo kunye nonyango ngaphambi kokuthatha i-berberine okanye nayiphi na enye into eyongezelelweyo.

Ngamana Ukuphucula iMpilo yokuTya ukutya

I-Berberine inokuthi izuze iinkxalabo zokugaya ukutya, njengokuqunjelwa kunyeisitshisa, ngokutsho kukaGqr McCubbins. "Ezi alkaloids zinokubonelela ngeenzuzo ezithembisayo kunxibelelwano lwe-gut-brain," uyongezelela, egxininisa ukubaluleka kwekhonkco phakathi kokugaya, isimo sengqondo kunye nempilo yonke.

Ngamana iNkxaso yokuLahla kobunzima kunye noLawulo loMzimba

I-Berberine inokunceda ukunciphisa ukugcinwa kwamafutha kunye ne-glucose ngokuphucula iinkqubo ze-metabolic, ezifana nokuqhekeka kwe-lipids (amafutha) kunye noshukela, uphando lucebisa. Impembelelo entle ye-Berberines kwi-gut microbiome inokuba yinto ephambili kwinkxaso yayo yokulawula ubunzima.

Ngamana ziphucula iimpawu ze-Polycystic Ovarian Syndrome (PCOS) kunye ne-Ovulation

Ngokophononongo kwiIimolekyuli, ukuthatha i-1,500 milligrams ye-berberine ngosuku ngeenyanga ezintathu kunciphisa amanqanaba aphezulu e-testosterone kubasetyhini abanePCOS[3]. Le meko inokubandakanya amanqanaba ehomoni yokuzala engaqhelekanga kwaye ibangele uluhlu lokungalingani, okukhokelela kwimiba efana namaqhakuva amancinci kuma-ovari okanye ukuya exesheni okungaqhelekanga. Iingcali zikholelwa ukuba i-berberine iphucula ukuxhathisa kwe-insulin, into eqhelekileyo ye-PCOS. Nangona kunjalo, abaphandi bacebisa ukuba uvavanyo olongezelelweyo lwekliniki luyafuneka ukuze kuqinisekiswe le mpembelelo ye-berberine, kubandakanywa ubude bonyango kunye ne-dosing yonyango.

 

Uyithatha njani iBerberine?

Izongezelelo zeBerberine zifumaneka kwi-capsule, ithebhulethi okanye ifom ye-tincture, evumela ukuba idosi echanekileyo kunye nokusetyenziswa lula. Iicapsules zinokukhethwa kuninzi lwabathengi ngenxa yencasa yayo ekrakra kakhulu, kuchaza uGqr McCubbins. "I-Berberine ihlala ithathwa njenge-tonic yokutya kwimizuzu emi-5 ukuya kwengama-30 ngaphambi kokutya. I-Berberine ngokwemvelo iyakrakra evuselela ijusi yesisu ukuze isebenze ngokufanelekileyo, "uqhubeka.

Umthamo weBerberine

Abantu kufuneka badibane nomboneleli wezempilo okanye i-herbalist ukuze baxoxe ngedosi echanekileyo (engekho semgangathweni), kwaye bafunde imiyalelo yomenzi, utsho uDkt. Zwickey. Ngokuqhelekileyo kuthathwa njengekhuselekile kwiidosi [zemihla ngemihla] [ezingekho ngaphezulu kwe] iigram ezi-2. Ukuze [ukufumana iziphumo ezizezona zilungileyo], umntu usenokufuna ukusebenzisa ubuncinane igram enye (1000 milligrams) ngosuku. Uninzi lwezongezo [ziqulathe] 500 milligrams nge capsule nganye, ngoko ke umntu angafuna ukuthatha [ezimbini] iicapsules ngemini,” uqhube watsho.

Idosi yeBerberine inokuxhomekeka kwiinjongo zempilo yomntu. Ngokumalunga neswekile yegazi, ukuphononongwa okucwangcisiweyo kwe-2019 kunye nohlalutyo lwe-meta kwiIjenali ye-EndocrineKufunyenwe ukuthatha ngaphantsi kwe-2 grams ye-berberine ngosuku kwiinyanga ezintathu ngokufanelekileyo kuchaphazele amanqanaba eglucose yegazi kubathathi-nxaxheba abanesifo seswekile se-2[4].

Ngeli xesha, uphononongo lophando olukhoyo kwiUnyango olongezelelweyo kwiKlinikhi yokuSebenzaivavanye impendulo yedosi yesicatshulwa se-berberine kubantu abatyebe kakhulu kwaye bafuna ukulawula ubunzima, bafumanisa ukuba iidosi ze-500 milligrams ezithathwe kathathu ngosuku zikhokelele ekunciphiseniIsalathisi sobunzima bomzimba (BMI), umjikelezo wesinqe kunye nobunzima bomzimba[5].

Berberine Side Effects

I-Berberine supplements ingaba nemiphumo ethile, kuquka urhudo, isisu esibuhlungu kunye nentloko, utsho uDkt McCubbins.

"I-Berberine ikhula ngokuthandwa kwaye ithengiswa kakhulu kuluntu lokunciphisa umzimba," uqhubeka. "Lumka kwaye udibane nogqirha we-naturopathic malunga nokusetyenziswa [kwe-berberine ngaphambi kokuba uyitye]."

Nangona i-berberine ivame ukunyamezela kakuhle, inokubangela intlungu yesisu kunye nokuphazamiseka, ukuxinwa, isifo sohudo, i-flatulence, isicaphucaphu kunye nokuhlanza, wongeza uDkt Zwickey.

Ngaba iBerberine ikhuselekile?

Inkxalabo ephambili yokhuseleko lwe-berberine kukuba inokusebenzisana namayeza amaninzi, utshilo uGqr Zwickey. Olona nxibelelwano lunamandla lunokubakho kunye ne-cyclosporine, ichiza le-immunosuppressive elisetyenziswa emva kokutshintshwa kwelungu kunye nokunceda ukulawula iimeko ze-autoimmune ezifanairheumatoid arthritis, njengoko i-berberine ikwandisa ukuxinwa kwe-cyclosporine egazini, uyachaza.

Nokuba umntu uthatha i-berberine njengeyongezelelo ekhutshwe ngokuzimeleyo okanye kwifomathi epheleleyo yemifuno, kubalulekile ukulandela imiyalelo yedosi ecetyiswayo enikwe ngumvelisi wemveliso okanye ingcali yezempilo. I-Berberine inqatshelwe abantwana, kunye nabantu abakhulelweyo nabancancisayo, uphawula uGqr Zwickey.

Yintoni omawuyithathele ingqalelo xa uthenga iBerberine?

Ngenxa yokuba abaninzi abavelisi behlambulula i-berberine kwisityalo, uvavanyo lwelabhoratri yomntu wesithathu ukuze uchonge i-berberine, amandla, umgangatho kunye nokucoceka kubalulekile, utsho uGqr Zwickey. "Umntu kufuneka acacise kakhulu malunga ne-supplement sourcing evela kwinkampani yokuncedisa ugqirha ukuqinisekisa ukuvavanywa komntu wesithathu kwiinkampani ezihloniphekileyo kunye nokuqinisekiswa komgangatho wommiselo [we-dosing] ogqwesileyo," wongezelela uGqr McCubbins.

Kwakhona kubalulekile ukuqinisekisa ukuba i-berberine ifunyenwe ngokuzinzileyo, ngokutsho kukaGqr McCubbins. "I-Goldenseal, nangona ingumthombo obalaseleyo we-berberine, isengozini. Iinkampani zoncediso ezaziwayo ziyawazi lo [mcimbi],” uyacacisa. Uninzi lweelebhile zokongeza zicacisa ukuba zeziphi iiherbs ezikhutshwa yiberberine.

Njengoko i-berberine iswele izifundo zokhuseleko lwexesha elide, umntu kufuneka adibane nomboneleli wezempilo ngaphambi kokuba afake i-berberine kwirejimeni yabo yokongeza ukuqinisekisa ukuba ifanelekile kwaye ikhuselekile kwiimfuno zabo ezizodwa zempilo. Ukufunda ngakumbi malunga neenzuzo zempilo ezinokuthi ze-berberine, thetha nogqirha we-naturopathic, i-herbalist eqinisekisiweyo okanye i-acupuncturist.